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Fermentation of fiber by gut bacteria also produces short-chain fatty acids that directly stimulate L-cells

Consistent with these pathological findings, both semaglutide and tirzepatide significantly lowered liver triglycerides (TG) and total cholesterol (TC) (Fig.4-C, D)

Patient-specific factors significantly influence the safety profiles of these agents

But it is more than that, Ive discussed the cardiovascular and renal benefits of tirzepatide when the SURPASS-CVOT data was published (GIP: SURPASSing all expectations) But now we have trials for asthma, depression, bipolar, schizophrenia, substance use disorders, peripheral arterial disease, back pain, osteoarthritis and even more autoimmune diseases